Optodynamic simulation of β-adrenergic receptor signalling

Optogenetics has provided a revolutionary approach to dissecting biological phenomena. However, the generation and use of optically active GPCRs in these contexts is limited and it is unclear how well an opsin-chimera GPCR might mimic endogenous receptor activity. Here we show that a chimeric rhodop...

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Udgivet i:Nat Commun
Main Authors: Siuda, Edward R., McCall, Jordan G., Al-Hasani, Ream, Shin, Gunchul, Il Park, Sung, Schmidt, Martin J., Anderson, Sonya L., Planer, William J., Rogers, John A., Bruchas, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588095/
https://ncbi.nlm.nih.gov/pubmed/26412387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9480
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