NH(4)Cl Treatment Prevents Tissue Calcification in Klotho Deficiency

Klotho, a cofactor in suppressing 1,25(OH)(2)D(3) formation, is a powerful regulator of mineral metabolism. Klotho-hypomorphic mice (kl/kl) exhibit excessive plasma 1,25(OH)(2)D(3), Ca(2+), and phosphate concentrations, severe tissue calcification, volume depletion with hyperaldosteronism, and early...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Leibrock, Christina B., Alesutan, Ioana, Voelkl, Jakob, Pakladok, Tatsiana, Michael, Diana, Schleicher, Erwin, Kamyabi-Moghaddam, Zahra, Quintanilla-Martinez, Leticia, Kuro-o, Makoto, Lang, Florian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2015
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587682/
https://ncbi.nlm.nih.gov/pubmed/25644113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014030230
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