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Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications
Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic stability and cancer development. Imbalanced dNTP pools can lead to enhanced mutagenesis and cell proliferation resulting in cancer development. Therapeutic agents that target dNTP synthesis and metabolism ar...
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| Veröffentlicht in: | Mol Cancer |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4587406/ https://ncbi.nlm.nih.gov/pubmed/26416562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0446-6 |
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