Elucidation of Enzymatic Mechanism of Phenazine Biosynthetic Protein PhzF Using QM/MM and MD Simulations

The phenazine biosynthetic pathway is of considerable importance for the pharmaceutical industry. The pathway produces two products: phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. PhzF is an isomerase that catalyzes trans-2,3-dihydro-3-hydroxyanthranilic acid isomerization and play...

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Vydáno v:PLoS One
Hlavní autoři: Liu, Fei, Zhao, Yi-Lei, Wang, Xiaolei, Hu, Hongbo, Peng, Huasong, Wang, Wei, Wang, Jing-Fang, Zhang, Xuehong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586147/
https://ncbi.nlm.nih.gov/pubmed/26414009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139081
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