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Arrhythmogenic effects of mutated L-type Ca(2+)-channels on an optogenetically paced muscular pump in Caenorhabditis elegans

Cardiac arrhythmias are often associated with mutations in ion channels or other proteins. To enable drug development for distinct arrhythmias, model systems are required that allow implementing patient-specific mutations. We assessed a muscular pump in Caenorhabditis elegans. The pharynx utilizes h...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Schüler, Christina, Fischer, Elisabeth, Shaltiel, Lior, Steuer Costa, Wagner, Gottschalk, Alexander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585839/
https://ncbi.nlm.nih.gov/pubmed/26399900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14427
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