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Insights to ligand binding to the monoamine transporters—from homology modeling to LeuBAT and dDAT

Understanding of drug binding to the human biogenic amine transporters (BATs) is essential to explain the mechanism of action of these pharmaceuticals but more importantly to be able to develop new and improved compounds to be used in the treatment of depression or drug addiction. Until recently no...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Koldsø, Heidi, Grouleff, Julie, Schiøtt, Birgit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585151/
https://ncbi.nlm.nih.gov/pubmed/26441663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00208
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