Novel Proteasome Inhibitors Have a Beneficial Effect in Murine Lupus via the dual inhibition of Type I Interferon and autoantibody secreting cells

OBJECTIVE: We postulated that proteasome inhibition (PI) may be useful in the treatment of SLE by targeting plasmacytoid dendritic cells (pDCs) and plasma cells (PCs), both critical to disease pathogenesis. METHODS: Lupus prone mice were treated with the non-selective PIs carfilzomib and bortezomib,...

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Veröffentlicht in:Arthritis Rheum
Hauptverfasser: Ichikawa, H. Travis, Conley, Thomas, Muchamuel, Tony, Jiang, Jing, Lee, Susan, Owen, Teresa, Barnard, Jennifer, Nevarez, Sarah, Goldman, Bruce I., Kirk, Christopher J., Looney, R. John, Anolik, Jennifer H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4584406/
https://ncbi.nlm.nih.gov/pubmed/21905015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33333
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