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Novel Proteasome Inhibitors Have a Beneficial Effect in Murine Lupus via the dual inhibition of Type I Interferon and autoantibody secreting cells
OBJECTIVE: We postulated that proteasome inhibition (PI) may be useful in the treatment of SLE by targeting plasmacytoid dendritic cells (pDCs) and plasma cells (PCs), both critical to disease pathogenesis. METHODS: Lupus prone mice were treated with the non-selective PIs carfilzomib and bortezomib,...
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| Publicado no: | Arthritis Rheum |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4584406/ https://ncbi.nlm.nih.gov/pubmed/21905015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33333 |
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