IgH sequences in common variable immune deficiency reveal altered B cell development and selection

Common variable immune deficiency (CVID) is the most common symptomatic primary immune deficiency, affecting ∼1 in 25,000 persons. These patients suffer from impaired antibody responses, autoimmunity, and susceptibility to lymphoid cancers. To explore the cellular basis for these clinical phenotypes...

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Udgivet i:Sci Transl Med
Main Authors: Roskin, Krishna M., Simchoni, Noa, Liu, Yi, Lee, Ji-Yeun, Seo, Katie, Hoh, Ramona A., Pham, Tho, Park, Joon H., Furman, David, Dekker, Cornelia L., Davis, Mark M., James, Judith A., Nadeau, Kari C., Cunningham-Rundles, Charlotte, Boyd, Scott D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4584259/
https://ncbi.nlm.nih.gov/pubmed/26311730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aab1216
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