Thrombin-induced microglial activation impairs hippocampal neurogenesis and spatial memory ability in mice

BACKGROUND: To investigate the effects of microglia/macrophages activation induced by intrastriatal thrombin injection on dentate gyrus neurogenesis and spatial memory ability in mice. METHODS: The male C57BL/6 mice were divided into 4 groups of 10: sham, intracerebral hemorrhage (ICH), ICH + hirudi...

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Bibliografiske detaljer
Udgivet i:Behav Brain Funct
Main Authors: Yang, Yuan, Zhang, Meikui, Kang, Xiaoni, Jiang, Chen, Zhang, Huan, Wang, Pei, Li, Jingjing
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4584127/
https://ncbi.nlm.nih.gov/pubmed/26410080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12993-015-0075-7
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