Granulocyte-Colony Stimulating Factor activates JAK2/PI3K/PDE3B Pathway to Inhibit Corticosterone Synthesis in a Neonatal Hypoxic-ischemic Brain Injury Rat Model

OBJECTIVE: Our previous study demonstrated that granulocyte-colony stimulating factor (G-CSF)-induced neuroprotection is accompanied by an inhibition of corticosterone production in a neonatal hypoxic-ischemic (HI) rat model. The present study investigates how G-CSF inhibits corticosterone productio...

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Pubblicato in:Exp Neurol
Autori principali: Charles, Mélissa S., Perera, Pradilka N Drunalini, Doycheva, Desislava Met, Tang, Jiping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583346/
https://ncbi.nlm.nih.gov/pubmed/25816736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.03.019
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