Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2

Breast Cancer is a complex multifactorial disease for which high-penetrance mutations have been identified. Approaches used to date have identified genomic features explaining about 50% of breast cancer heritability. A number of low- to medium penetrance alleles (per-allele odds ratio < 1.5 and 4...

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Publicado no:PLoS One
Main Authors: Blein, Sophie, Barjhoux, Laure, Damiola, Francesca, Dondon, Marie-Gabrielle, Eon-Marchais, Séverine, Marcou, Morgane, Caron, Olivier, Lortholary, Alain, Buecher, Bruno, Vennin, Philippe, Berthet, Pascaline, Noguès, Catherine, Lasset, Christine, Gauthier-Villars, Marion, Mazoyer, Sylvie, Stoppa-Lyonnet, Dominique, Andrieu, Nadine, Thomas, Gilles, Sinilnikova, Olga M., Cox, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583250/
https://ncbi.nlm.nih.gov/pubmed/26406445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136192
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