Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their intracellular domain. Here, we investigate the involvement of beta2-integrins in the regulation of metabolic disease using mice where the ki...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Meakin, Paul J., Morrison, Vicky L., Sneddon, Claire C., Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M., Gabriel, Jennie L., Kang, Li, Ashford, Michael L. J., Fagerholm, Susanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583187/
https://ncbi.nlm.nih.gov/pubmed/26405763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138872
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