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Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(−/−) mice by targeting the TGFβ-Smad3 pathway
DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr(−/−) mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA a...
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| Udgivet i: | J Lipid Res |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4583081/ https://ncbi.nlm.nih.gov/pubmed/26315048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061275 |
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