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Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(−/−) mice by targeting the TGFβ-Smad3 pathway

DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr(−/−) mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA a...

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Foilsithe in:J Lipid Res
Main Authors: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., Jump, Donald B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583081/
https://ncbi.nlm.nih.gov/pubmed/26315048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061275
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