Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

In vitro preclinical models for the assessment of drug-induced liver injury (DILI) are usually based on cryopreserved primary human hepatocytes (cPHH) or human hepatic tumor-derived cell lines; however, it is unclear how well such cell models reflect the normal function of liver cells. The physiolog...

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Bibliografiska uppgifter
I publikationen:Toxicol Sci
Huvudupphovsmän: Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Proteomic Evaluation of Cellular Liver Toxicity Models
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583060/
https://ncbi.nlm.nih.gov/pubmed/26160117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv136
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