The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfide-bonded protein synthesized at the endoplas...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Torres, Mauricio, Medinas, Danilo B., Matamala, José Manuel, Woehlbier, Ute, Cornejo, Víctor Hugo, Solda, Tatiana, Andreu, Catherine, Rozas, Pablo, Matus, Soledad, Muñoz, Natalia, Vergara, Carmen, Cartier, Luis, Soto, Claudio, Molinari, Maurizio, Hetz, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583042/
https://ncbi.nlm.nih.gov/pubmed/26170458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635565
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