Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin

Directed delivery of EGF receptor (EGFR) ligands to the apical or basolateral surface is a crucial regulatory step in the initiation of EGFR signaling in polarized epithelial cells. Herein, we show that the EGFR ligand betacellulin (BTC) is preferentially sorted to the basolateral surface of polariz...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Singh, Bhuminder, Bogatcheva, Galina, Starchenko, Alina, Sinnaeve, Justine, Lapierre, Lynne A., Williams, Janice A., Goldenring, James R., Coffey, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582402/
https://ncbi.nlm.nih.gov/pubmed/26272915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.170852
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