Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib

Mantle cell lymphoma (MCL) cells exhibit increased B-cell receptor and nuclear factor (NF)-κB activities. The bromodomain and extra-terminal (BET) protein bromodomain 4 is essential for the transcriptional activity of NF-κB. Here, we demonstrate that treatment with the BET protein bromodomain antago...

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Veröffentlicht in:Blood
Hauptverfasser: Sun, Baohua, Shah, Bhavin, Fiskus, Warren, Qi, Jun, Rajapakshe, Kimal, Coarfa, Cristian, Li, Li, Devaraj, Santhana G. T., Sharma, Sunil, Zhang, Liang, Wang, Michael L., Saenz, Dyana T., Krieger, Stephanie, Bradner, James E., Bhalla, Kapil N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582333/
https://ncbi.nlm.nih.gov/pubmed/26254443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639542
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