Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

During vertebrate development, mesodermal fate choices are regulated by interactions between morphogens such as activin/nodal, BMPs and Wnt/β-catenin that define anterior-posterior patterning and specify downstream derivatives including cardiomyocyte, endothelial and hematopoietic cells. We used hum...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Palpant, Nathan J., Pabon, Lil, Roberts, Meredith, Hadland, Brandon, Jones, Daniel, Jones, Christina, Moon, Randall T., Ruzzo, Walter L., Bernstein, Irwin, Zheng, Ying, Murry, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Stem Cells and Regeneration
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582173/
https://ncbi.nlm.nih.gov/pubmed/26153229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117010
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