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Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway

Huntington disease (HD) is a brain disorder characterized by the late onset of motor and cognitive symptoms, even though the neurons in the brain begin to suffer dysfunction and degeneration long before symptoms appear. There is currently no cure. Several molecular and developmental effects of HD ha...

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Bibliografski detalji
Izdano u:Dis Model Mech
Glavni autori: Szlachcic, Wojciech J., Switonski, Pawel M., Krzyzosiak, Wlodzimierz J., Figlerowicz, Marek, Figiel, Maciej
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582098/
https://ncbi.nlm.nih.gov/pubmed/26092128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019406
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