Relationship Between Serum Concentrations of Nitisinone and Its Effect on Homogentisic Acid and Tyrosine in Patients with Alkaptonuria

Background: Alkaptonuria (AKU) is a serious genetic disease due to a defect in tyrosine metabolism, leading to increased serum levels of homogentisic acid (HGA). Nitisinone decreases HGA in AKU, but the concentration–response relationship has not been previously reported. Objectives: To determine th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JIMD Rep
Prif Awduron: Olsson, Birgitta, Cox, Trevor F, Psarelli, Eftychia E, Szamosi, Johan, Hughes, Andrew T, Milan, Anna M, Hall, Anthony K, Rovensky, Jozef, Ranganath, Lakshminarayan R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582028/
https://ncbi.nlm.nih.gov/pubmed/25772318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/8904_2015_412
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