Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation

Common variable immunodeficiency (CVID) is a late-onset humoral deficiency characterized by B lymphocyte dysfunction or loss, decreased immunoglobulin production, and recurrent bacterial infections. CVID is the most frequent human primary immunodeficiency but still presents challenges in the underst...

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Veröffentlicht in:Clin Immunol
Hauptverfasser: Tallmadge, Rebecca L., Shen, Lishuang, Tseng, Chia T., Miller, Steven C., Barry, Jay, Felippe, M. Julia B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581901/
https://ncbi.nlm.nih.gov/pubmed/25988861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.05.005
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