Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas

Pediatric bone and soft tissue sarcomas often display increased Akt phosphorylation through up regulation of insulin-like growth factor (IGF1) signaling. Additionally, Akt signaling has been linked to resistance to IGF1 receptor (IGF1R) and mTOR (mammalian target of rapamycin) inhibitors in sarcoma,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Anderson, Jennifer L., Park, Ann, Akiyama, Ryan, Tap, William D., Denny, Christopher T., Federman, Noah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581723/
https://ncbi.nlm.nih.gov/pubmed/26402468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133610
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