Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo

Abnormal axonal connectivity and hyperactive mTOR complex 1 (mTORC1) are shared features of several neurological disorders. Hyperactive mTORC1 alters axon length and polarity of hippocampal neurons in vitro, but the impact of hyperactive mTORC1 on axon growth in vivo and the mechanisms underlying th...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Gong, Xuan, Zhang, Longbo, Huang, Tianxiang, Lin, Tiffany V., Miyares, Laura, Wen, John, Hsieh, Lawrence, Bordey, Angélique
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581604/
https://ncbi.nlm.nih.gov/pubmed/26220974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv295
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