MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR

Abnormal dendritic complexity is a shared feature of many neurodevelopmental disorders associated with neurological defects. Here, we found that the actin-crosslinking protein filamin A (FLNA) is overexpressed in tuberous sclerosis complex (TSC) mice, a PI3K-mTOR model of neurodevelopmental disease...

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Detalhes bibliográficos
Main Authors: Zhang, Longbo, Bartley, Christopher M., Gong, Xuan, Hsieh, Lawrence S., Lin, Tiffany V., Feliciano, David M., Bordey, Angélique
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185153/
https://ncbi.nlm.nih.gov/pubmed/25277454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.09.009
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