Characterizing of Four Common BCR-ABL Kinase Domain Mutations (T315I, Y253H, M351T and E255K) in Iranian Chronic Myelogenous Leukemia Patients With Imatinib Resistance

BACKGROUND: Chronic myelogenous leukemia (CML) is a kind of hematopoietic stem-cell cancer. A significant number of CML patients who do not achieve an acceptable response to therapy, show acquired resistance against Imatinib. One of the most considerable causes of resistance against Imatinib as the...

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Veröffentlicht in:Iran J Cancer Prev
Hauptverfasser: Rejali, Leili, Poopak, Behzad, Hasanzad, Mandana, Sheikhsofla, Fatemeh, Varnoosfaderani, Ameneh Saadat, Safari, Nazila, Rabieipoor, Saghar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Shahid Beheshti University of Medical Sciences 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581365/
https://ncbi.nlm.nih.gov/pubmed/26413254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17795/ijcp2334
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