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Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis

Whales have 1000-fold more cells than humans and mice have 1000-fold fewer; however, cancer risk across species does not increase with the number of somatic cells and the lifespan of the organism. This observation is known as Peto's paradox. How much would evolution have to change the parameter...

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Podrobná bibliografie
Vydáno v:Philos Trans R Soc Lond B Biol Sci
Hlavní autoři: Caulin, Aleah F., Graham, Trevor A., Wang, Li-San, Maley, Carlo C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581027/
https://ncbi.nlm.nih.gov/pubmed/26056366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0222
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