Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer

BACKGROUND: There is evidence that tumour–stroma interactions have a major role in the neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding is thought to reflect the process of epithelial–mesenchymal transition (EMT); however, the relationship between tumour buds and EMT...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Galván, J A, Zlobec, I, Wartenberg, M, Lugli, A, Gloor, B, Perren, A, Karamitopoulou, E
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580384/
https://ncbi.nlm.nih.gov/pubmed/25989272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.177
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