Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)

BACKGROUND: Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers and is known to inhibit Ras/Raf/MEK/ERK signaling. By suppressing the activation of the NFkB/SNAIL circuit, RKIP can regulate the induction of epithelial-mesenchymal tra...

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Detalhes bibliográficos
Main Authors: Karamitopoulou, Eva, Zlobec, Inti, Gloor, Beat, Kondi-Pafiti, Agathi, Lugli, Alessandro, Perren, Aurel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898115/
https://ncbi.nlm.nih.gov/pubmed/24330423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-311
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