An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs

The NS1 protein of influenza virus has multiple functions and is a determinant of virulence. Influenza viruses with NS1 deletions (DelNS1 influenza viruses) are a useful tool for studying virus replication and can serve as effective live attenuated vaccines, but deletion of NS1 severely diminishes v...

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Bibliographic Details
Published in:J Virol
Main Authors: Zheng, Min, Wang, Pui, Song, Wenjun, Lau, Siu-Ying, Liu, Siwen, Huang, Xiaofeng, Mok, Bobo Wing-Yee, Liu, Yen-Chin, Chen, Yixin, Yuen, Kwok-Yung, Chen, Honglin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580205/
https://ncbi.nlm.nih.gov/pubmed/26223635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00919-15
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