Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

Genomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampus in vivo. In the SVZ, paracrine IGF2 is a cerebros...

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Udgivet i:Nat Commun
Main Authors: Ferrón, S. R., Radford, E. J., Domingo-Muelas, A., Kleine, I., Ramme, A., Gray, D., Sandovici, I., Constancia, M., Ward, A., Menheniott, T. R., Ferguson-Smith, A. C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579569/
https://ncbi.nlm.nih.gov/pubmed/26369386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9265
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