Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT(3), 5-HT(7) and 5-HT(1D) receptor antagonism, 5-HT(1B) receptor partial agonism, and 5-HT(1A) receptor agonism, had fewer incidences of sleep-related adv...

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Detalhes bibliográficos
Publicado no:J Psychopharmacol
Main Authors: Leiser, Steven C, Iglesias-Bregna, Deborah, Westrich, Ligia, Pehrson, Alan L, Sanchez, Connie
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579402/
https://ncbi.nlm.nih.gov/pubmed/26174134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881115592347
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