Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA

The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a chall...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Doritchamou, Justin, Sabbagh, Audrey, Jespersen, Jakob S., Renard, Emmanuelle, Salanti, Ali, Nielsen, Morten A., Deloron, Philippe, Tuikue Ndam, Nicaise
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579133/
https://ncbi.nlm.nih.gov/pubmed/26393516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137695
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