Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

BACKGROUND: Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Darton, Thomas C., Blohmke, Christoph J., Giannoulatou, Eleni, Waddington, Claire S., Jones, Claire, Sturges, Pamela, Webster, Craig, Drakesmith, Hal, Pollard, Andrew J., Armitage, Andrew E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578949/
https://ncbi.nlm.nih.gov/pubmed/26394303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004029
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