Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis

BACKGROUND: Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Erson-Omay, E. Zeynep, Çağlayan, Ahmet Okay, Schultz, Nikolaus, Weinhold, Nils, Omay, S. Bülent, Özduman, Koray, Köksal, Yavuz, Li, Jie, Serin Harmancı, Akdes, Clark, Victoria, Carrión-Grant, Geneive, Baranoski, Jacob, Çağlar, Caner, Barak, Tanyeri, Coşkun, Süleyman, Baran, Burçin, Köse, Doğan, Sun, Jia, Bakırcıoğlu, Mehmet, Moliterno Günel, Jennifer, Pamir, M. Necmettin, Mishra-Gorur, Ketu, Bilguvar, Kaya, Yasuno, Katsuhito, Vortmeyer, Alexander, Huttner, Anita J., Sander, Chris, Günel, Murat
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578578/
https://ncbi.nlm.nih.gov/pubmed/25740784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov027
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