Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis

BACKGROUND: Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Erson-Omay, E. Zeynep, Çağlayan, Ahmet Okay, Schultz, Nikolaus, Weinhold, Nils, Omay, S. Bülent, Özduman, Koray, Köksal, Yavuz, Li, Jie, Serin Harmancı, Akdes, Clark, Victoria, Carrión-Grant, Geneive, Baranoski, Jacob, Çağlar, Caner, Barak, Tanyeri, Coşkun, Süleyman, Baran, Burçin, Köse, Doğan, Sun, Jia, Bakırcıoğlu, Mehmet, Moliterno Günel, Jennifer, Pamir, M. Necmettin, Mishra-Gorur, Ketu, Bilguvar, Kaya, Yasuno, Katsuhito, Vortmeyer, Alexander, Huttner, Anita J., Sander, Chris, Günel, Murat
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578578/
https://ncbi.nlm.nih.gov/pubmed/25740784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov027
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