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Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
BACKGROUND: Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into...
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| Publié dans: | Neuro Oncol |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4578578/ https://ncbi.nlm.nih.gov/pubmed/25740784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov027 |
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