Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis

BACKGROUND: Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Neuro Oncol
المؤلفون الرئيسيون: Erson-Omay, E. Zeynep, Çağlayan, Ahmet Okay, Schultz, Nikolaus, Weinhold, Nils, Omay, S. Bülent, Özduman, Koray, Köksal, Yavuz, Li, Jie, Serin Harmancı, Akdes, Clark, Victoria, Carrión-Grant, Geneive, Baranoski, Jacob, Çağlar, Caner, Barak, Tanyeri, Coşkun, Süleyman, Baran, Burçin, Köse, Doğan, Sun, Jia, Bakırcıoğlu, Mehmet, Moliterno Günel, Jennifer, Pamir, M. Necmettin, Mishra-Gorur, Ketu, Bilguvar, Kaya, Yasuno, Katsuhito, Vortmeyer, Alexander, Huttner, Anita J., Sander, Chris, Günel, Murat
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2015
الموضوعات:
Basic and Translational Investigations
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578578/
https://ncbi.nlm.nih.gov/pubmed/25740784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov027
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