YAP controls retinal stem cell DNA replication timing and genomic stability

The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Cabochette, Pauline, Vega-Lopez, Guillermo, Bitard, Juliette, Parain, Karine, Chemouny, Romain, Masson, Christel, Borday, Caroline, Hedderich, Marie, Henningfeld, Kristine A, Locker, Morgane, Bronchain, Odile, Perron, Muriel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2015
Onderwerpen:
Developmental Biology and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578106/
https://ncbi.nlm.nih.gov/pubmed/26393999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08488
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