YAP controls retinal stem cell DNA replication timing and genomic stability

The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Cabochette, Pauline, Vega-Lopez, Guillermo, Bitard, Juliette, Parain, Karine, Chemouny, Romain, Masson, Christel, Borday, Caroline, Hedderich, Marie, Henningfeld, Kristine A, Locker, Morgane, Bronchain, Odile, Perron, Muriel
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Developmental Biology and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578106/
https://ncbi.nlm.nih.gov/pubmed/26393999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08488
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi