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YAP controls retinal stem cell DNA replication timing and genomic stability
The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal...
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| Gepubliceerd in: | eLife |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications, Ltd
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4578106/ https://ncbi.nlm.nih.gov/pubmed/26393999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08488 |
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