Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. METHODS: APC prognostic value was evaluated in 746 stage I–IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to id...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Jorissen, Robert N, Christie, Michael, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Li, Shan, Love, Christopher, Xu, Zheng-Zhou, Molloy, Peter L, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Burgess, Antony W, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Lipton, Lara, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Genetics & Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578087/
https://ncbi.nlm.nih.gov/pubmed/26305864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.296
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