Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. METHODS: APC prognostic value was evaluated in 746 stage I–IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to id...

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Publicado en:Br J Cancer
Autores principales: Jorissen, Robert N, Christie, Michael, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Li, Shan, Love, Christopher, Xu, Zheng-Zhou, Molloy, Peter L, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Burgess, Antony W, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Lipton, Lara, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
Materias:
Genetics & Genomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578087/
https://ncbi.nlm.nih.gov/pubmed/26305864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.296
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