Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. METHODS: APC prognostic value was evaluated in 746 stage I–IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to id...

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Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Jorissen, Robert N, Christie, Michael, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Li, Shan, Love, Christopher, Xu, Zheng-Zhou, Molloy, Peter L, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Burgess, Antony W, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Lipton, Lara, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Genetics & Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578087/
https://ncbi.nlm.nih.gov/pubmed/26305864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.296
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