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Experimental Evolution Identifies Vaccinia Virus Mutations in A24R and A35R That Antagonize the Protein Kinase R Pathway and Accompany Collapse of an Extragenic Gene Amplification

Most new human infectious diseases emerge from cross-species pathogen transmissions; however, it is not clear how viruses adapt to productively infect new hosts. Host restriction factors represent one species-specific barrier that viruses may initially have little ability to inhibit in new hosts. Fo...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Brennan, Greg, Kitzman, Jacob O., Shendure, Jay, Geballe, Adam P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577882/
https://ncbi.nlm.nih.gov/pubmed/26202237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01233-15
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