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Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear. Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's...
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| Gepubliceerd in: | eLife |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications, Ltd
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577825/ https://ncbi.nlm.nih.gov/pubmed/26297804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08142 |
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