Redox-induced activation of the proton pump in the respiratory complex I

Complex I functions as a redox-linked proton pump in the respiratory chains of mitochondria and bacteria, driven by the reduction of quinone (Q) by NADH. Remarkably, the distance between the Q reduction site and the most distant proton channels extends nearly 200 Å. To elucidate the molecular origin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Sharma, Vivek, Belevich, Galina, Gamiz-Hernandez, Ana P., Róg, Tomasz, Vattulainen, Ilpo, Verkhovskaya, Marina L., Wikström, Mårten, Hummer, Gerhard, Kaila, Ville R. I.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577180/
https://ncbi.nlm.nih.gov/pubmed/26330610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503761112
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