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Lead-Induced Cell Cycle Arrest in Human Liver Carcinoma (HepG(2)) Cells: Involvement of oxidative stress, p53 and Cyclin A

BACKGROUND: Recent studies in our laboratory have demonstrated that lead is cytotoxic to human liver carcinoma (HepG(2)) cells, showing a 48 h-LD(50) of 35.5 ± 9.2ug/mL. However, its molecular mechanisms of toxicity are still largely unknown. Hence, the aim of the present study was to use HepG(2) ce...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Met Ions Biol Med
Prif Awduron: Yedjou, Clement G., Tchounwou, Paul B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577017/
https://ncbi.nlm.nih.gov/pubmed/26401103
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