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Lead-Induced Cell Cycle Arrest in Human Liver Carcinoma (HepG(2)) Cells: Involvement of oxidative stress, p53 and Cyclin A
BACKGROUND: Recent studies in our laboratory have demonstrated that lead is cytotoxic to human liver carcinoma (HepG(2)) cells, showing a 48 h-LD(50) of 35.5 ± 9.2ug/mL. However, its molecular mechanisms of toxicity are still largely unknown. Hence, the aim of the present study was to use HepG(2) ce...
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| Publicado no: | Met Ions Biol Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577017/ https://ncbi.nlm.nih.gov/pubmed/26401103 |
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