Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Antisense oligonucleotide (AON)-induced exon skipping is one of the most promising strategies for treating Duchenne muscular dystrophy (DMD) and other rare monogenic conditions. Phosphorodiamidate morpholino oligonucleotides (PMOs) and 2′-O-methyl phosphorothioate (2′OMe) are two of the most advance...

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Detalles Bibliográficos
Publicado en:Nucleic Acid Ther
Autores principales: Burki, Umar, Keane, Jonathan, Blain, Alison, O'Donovan, Liz, Gait, Michael John, Laval, Steven H., Straub, Volker
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Methods
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576940/
https://ncbi.nlm.nih.gov/pubmed/26176274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0528
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