Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide–High Angiotensin II–Induced Cardiovascular Injury

Aldosterone interacts with mineralocorticoid receptor (MR) to stimulate sodium reabsorption in renal tubules and may also affect the vasculature. Caveolin-1 (cav-1), an anchoring protein in plasmalemmal caveolae, binds steroid receptors and also endothelial nitric oxide synthase, thus limiting its t...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Pojoga, Luminita H., Yao, Tham M., Opsasnick, Lauren A., Siddiqui, Waleed T., Reslan, Ossama M., Adler, Gail K., Williams, Gordon H., Khalil, Raouf A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576669/
https://ncbi.nlm.nih.gov/pubmed/26183312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.226043
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