Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

BACKGROUND: Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogene...

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Vydáno v:Genome Biol
Hlavní autoři: Tsang, Jason C. H., Yu, Yong, Burke, Shannon, Buettner, Florian, Wang, Cui, Kolodziejczyk, Aleksandra A., Teichmann, Sarah A., Lu, Liming, Liu, Pentao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576406/
https://ncbi.nlm.nih.gov/pubmed/26387834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0739-5
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