Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea

STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with the progression of nonalcoholic fatty liver disease (NAFLD). We hypothesized that the hypoxia of OSA increases hepatic production of lysyl oxidase (LOX), an enzyme that cross-links collagen, and that LOX may serve as a biomarker of h...

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Bibliographic Details
Published in:Sleep
Main Authors: Mesarwi, Omar A., Shin, Mi-Kyung, Drager, Luciano F., Bevans-Fonti, Shannon, Jun, Jonathan C., Putcha, Nirupama, Torbenson, Michael S., Pedrosa, Rodrigo P., Lorenzi-Filho, Geraldo, Steele, Kimberley E., Schweitzer, Michael A., Magnuson, Thomas H., Lidor, Anne O., Schwartz, Alan R., Polotsky, Vsevolod Y.
Format: Artigo
Language:Inglês
Published: Associated Professional Sleep Societies, LLC 2015
Subjects:
Lysyl Oxidase as a Biomarker of Liver Fibrosis in Severely Obese Patients with OSA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576332/
https://ncbi.nlm.nih.gov/pubmed/26085300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.5052
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