Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea

STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with the progression of nonalcoholic fatty liver disease (NAFLD). We hypothesized that the hypoxia of OSA increases hepatic production of lysyl oxidase (LOX), an enzyme that cross-links collagen, and that LOX may serve as a biomarker of h...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Mesarwi, Omar A., Shin, Mi-Kyung, Drager, Luciano F., Bevans-Fonti, Shannon, Jun, Jonathan C., Putcha, Nirupama, Torbenson, Michael S., Pedrosa, Rodrigo P., Lorenzi-Filho, Geraldo, Steele, Kimberley E., Schweitzer, Michael A., Magnuson, Thomas H., Lidor, Anne O., Schwartz, Alan R., Polotsky, Vsevolod Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2015
Assuntos:
Lysyl Oxidase as a Biomarker of Liver Fibrosis in Severely Obese Patients with OSA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576332/
https://ncbi.nlm.nih.gov/pubmed/26085300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.5052
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