Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea

STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with the progression of nonalcoholic fatty liver disease (NAFLD). We hypothesized that the hypoxia of OSA increases hepatic production of lysyl oxidase (LOX), an enzyme that cross-links collagen, and that LOX may serve as a biomarker of h...

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Bibliografische gegevens
Gepubliceerd in:Sleep
Hoofdauteurs: Mesarwi, Omar A., Shin, Mi-Kyung, Drager, Luciano F., Bevans-Fonti, Shannon, Jun, Jonathan C., Putcha, Nirupama, Torbenson, Michael S., Pedrosa, Rodrigo P., Lorenzi-Filho, Geraldo, Steele, Kimberley E., Schweitzer, Michael A., Magnuson, Thomas H., Lidor, Anne O., Schwartz, Alan R., Polotsky, Vsevolod Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Associated Professional Sleep Societies, LLC 2015
Onderwerpen:
Lysyl Oxidase as a Biomarker of Liver Fibrosis in Severely Obese Patients with OSA
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576332/
https://ncbi.nlm.nih.gov/pubmed/26085300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.5052
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