Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes

Cyclin-dependent kinases (CDKs) and their associated regulatory cyclins are central for timely regulation of cell-cycle progression. They constitute attractive pharmacological targets for development of anticancer therapeutics, since they are frequently deregulated in human cancers and contribute to...

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Bibliographic Details
Published in:Biophys J
Main Authors: Floquet, Nicolas, Costa, Mauricio G.S., Batista, Paulo R., Renault, Pedro, Bisch, Paulo M., Raussin, Florent, Martinez, Jean, Morris, May C., Perahia, David
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576171/
https://ncbi.nlm.nih.gov/pubmed/26255588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.003
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