Lumefantrine and Desbutyl-Lumefantrine Population Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria on the Thailand-Myanmar Border

Artemether-lumefantrine is the most widely used antimalarial artemisinin-based combination treatment. Recent studies have suggested that day 7 plasma concentrations of the potent metabolite desbutyl-lumefantrine correlate better with treatment outcomes than those of lumefantrine. Low cure rates have...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Kloprogge, Frank, McGready, Rose, Hanpithakpong, Warunee, Blessborn, Daniel, Day, Nicholas P. J., White, Nicholas J., Nosten, François, Tarning, Joel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576090/
https://ncbi.nlm.nih.gov/pubmed/26239986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00267-15
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